NO Targets SIRT1

NO targets SIRT1: a novel signaling network in endothelial senescence.

Aging is considered to be a major risk factor for the development of cardiovascular diseases, the leading cause of morbidity and mortality in Western countries. Among the age-associated functional and structural changes in the vascular wall, particularly endothelial function declines during the ageing process. Impairment of endothelial function critically contributes to the pathogenesis of seve...

SIRT1 and SIRT2: emerging targets in neurodegeneration

Sirtuins are NAD-dependent protein deacetylases known to have protective effects against age-related diseases such as cancer, diabetes, cardiovascular and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. While SIRT1 has been extensively investigated due to its initial connection with lifespan extension ...

Multiple SIRT1 Targets Encephalomyelitis through Activation of Protects against Experimental Autoimmune Overexpression of SIRT1 Protein in Neurons

Sirt1

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signal...

A ChIP-cloning approach linking SIRT1 to transcriptional modificationof DNA targets.

The mammalian protein deacetylase SIRT1 (sirtuin1) is widely recognized for its link to calorie restriction and longevity. SIRT1 not only modulates the function of protein targets such as p53 or NFkappaB, but it also affects gene transcription by causing hypoacetylation of associated nucleosomal histones. However, the identification of SIRT1-specific DNA targets that confer chromosomal stabilit...